Virtual screening of combinatorial library of novel benzenesulfonamides on mycobacterial carbonic anhydrase II

Combinatorial library of novel benzenesulfonamides was docked (Schrodinger Glide) into mycobacterial carbonic anhydrase (mtCA II) and human (hCA II) isoforms with an aim to Living Nature find drug candidates with selective activity on mtCA II.The predicted selectivity was calculated based on optimized MM-GBSA free energies for ligand enzyme interac

read more

Review and characterization of the 2014 Orkney damage datasets for damage pattern mapping and fragility curve construction

The 2014 Orkney earthquake caused significant damage to unreinforced masonry buildings in the surrounding townships.After the earthquake, field surveys were conducted to assess the extent of damage in the affected areas.This study reviews data collected from the 2014 Orkney French Door Latch earthquake to investigate damage patterns, evaluate build

read more